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=Welcome to the CREU 2010-UMBC Wikispace!= We have received funding from the CDC and CRA-W to complete a project in the 2010-2011 academic year. We are very grateful to the CDC and CRA-W for this opportunity. Here is some information about our project.

**Project Title** //Multivariate time series analysis of physiological and clinical data to predict patent ductus arteriosus (PDA) in neo-natal patients//

**Participants**
 * //**Marie desJardins**//, PhD, Associate Professor, Computer Science, University of Maryland, Baltimore County (UMBC)
 * //**Kathryn Holmes**//, M.D., MPH ,Assistant Professor of Pediatric Cardiology, Johns Hopkins University
 * //**Patricia Ordóñez Rozo**//, PhD Candidate, Computer Science, UMBC
 * //**Erica George**//, Undergraduate, Biochemistry and Molecular Biology, UMBC
 * **//Chris Mai//**, Undergraduate, Computer Science, UMBC
 * **//Imaobong A. Udofa//**, Undergraduate, Computer Engineering, UMBC
 * **//Ofek Lev//**, Undergraduate, Computer Science, UMBC

A persistent patent ductus arteriosus results in lack of closure of the ductus arteriosus after birth. Depending on the pulmonary vascular resistance, a patent ductus arteriosus (PDA) may result in a significant left to right shunt in the newborn infant. In premature infants, a patent ductus arteriosus can contribute to considerable morbidity and mortality including, high output heart failure, intracranial hemorrhage, respiratory failure, necrotizing enterocolitis and renal insufficiency. Recognition of a patent ductus arteriosus is made clinically with echocardiographic imaging as gold standard.
 * Project Description**

Therapeutic interventions include prostaglandin inhibitors and surgical ligation. As many patients require transfer to another center for surgical intervention, it is important to recognize these infants early in their course in order to avoid delay of care. Given the ability to track patient hemodynamic and laboratory parameters via computerized data collection, we hypothesize that there is a pattern that is predictive of patients who will be unresponsive to pharmacological closure. The ultimate goal is to improve quality of patient care with the identification of a clinical pattern predictive of a PDA and determine whether that PDA is amenable to either pharmacological closure versus surgical closure. **Project Website** []

**Student Blogs** Chris' Blog - http://chrmai1.wordpress.com/ Erica's Blog - http://egeorgecreu2010.wordpress.com/ Ima's Blog - http://imz7.wordpress.com/ Ofek's Blog - []